• Key factor in several key biological pathways, including methylation reactions, glutathione formation and glutathione-s-transferase activity* • Complexed with disulfate tosylate, a well-tolerated, stable and clinically tested form • Enteric coating protects SAMe degradation from gastric acid, allowing for significantly improved intestinal absorption* • 200 mg SAMe per tablet, allows for flexible dose titration • Sourced from the highest quality Italian Isoactive SAMe available on the market • Isoactive SAMe uses a natural fermentation process that yields 40% higher active ingredients over synthetic variations • Suitable for vegetarians/vegans

Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.If you are taking antidepressant medications, consult a health care professional prior to taking SAMe in place of or in addition to those medications. Not recommended for use in children. Do not use if you are pregnant or breastfeeding. Do not take at night as SAMe may cause anxiety, restlessness, insomnia. People with bipolar disorder or (manic-depressive illness) should not use SAMe unless under medical supervision. Possible side effects are: mild gastrointestinal upsets, anxiety, hyperactive muscle movement, insomnia and hypomania. When these side effects occur, they often diminish with time or resolve with lower doses or cessation of use. There are no documented cases of allergies to SAMe. SAMe could theoretically worsen Parkinson’s symptoms, although this has not been observed clinically. Keep out of reach of children.Deficiency of vitamins B6, B12, and other methyl donors may exacerbate SAMe deficiency. Theoretically may have additive serotonergic effects when used with antidepressants, but this has not been observed clinically, and when used simultaneously, no increase in adverse effects were noted compared to placebo.