††USA Functional Medicine MDs, DOs, NDs, DCs and Nutrition Professionals surveyed in 2025 for Designs for Health.Designs for Health’s most advanced vitamin K2 formula that targets bone health with clinically studied bone remodeling factors (BRF).* BRF 45™ features 45 mg of vitamin K2 (as MK-4), the research-backed amount shown to promote bone health and strength, arterial health, and help discourage age- and hormone-related bone breakdown in women and men, such as during menopause and andropause.* Vitamins K1 and geranylgeraniol are also included to support conversion to vitamin K2 (as MK-4).* BRF 45™ may provide nutritional support for individuals who are at risk of bone loss, bone fracture, arterial stiffness, and other relevant conditions in which high amounts of vitamin K1 and/or vitamin K2 may be beneficial.*

At least twice a day (once first thing in the morning and another test one to two hours after a nitrate containing supplement or meal). Can be used multiple times a day for hourly or daily monitoring.