††USA Functional Medicine MDs, DOs, NDs, DCs and Nutrition Professionals surveyed in 2025 for Designs for Health.Lithium orotate is lithium bound to orotic acid, which improves its bioavailability. It is thought that some of the nutritional benefits of lithium come from its ability to support the synthesis and recycling of inositol, a primary component of the phosphoinositol signaling pathway. Research also shows that lithium supports the health and function of the hippocampus. The addition of vitamin B12 and trimethylglycine (TMG) to Lithium Synergy helps support healthy methylation pathways; vitamin B12 is also needed for the synthesis of SAMe.

WARNING This product should not be used to replace any antidepressant medication, including prescription forms of lithium, unless under direction of a qualified health care practitioner. Lithium Synergy should not be used by individuals with significant renal or cardiovascular diseases, severe debilitation, dehydration or sodium depletion, or by individuals who are taking diuretics or ACE inhibitors. Consult your doctor before use if you are taking antihypertensive drugs, antiinflammatory drugs, analgesic drugs or insulin. Lithium should not be used by pregnant women and breast-feeding mothers. Serum lithium levels should be monitored by qualified health care provider during use. NOTICE Color, size or shape may appear different between lots. Store at room temperature. Keep out of reach of children.