Biotin is an unnumbered member of the water soluble B-complex family, normally only required in minute amounts. Biotin is used as a cofactor of enzymes involved in fatty acid metabolism, gluconeogenesis, and amino acid catabolism, and is essential in maintaining metabolic homeostasis.1-4 Biotin plays an important role in metabolic functioning as a coenzyme carrier of activated carbon dioxide in the TCA cycle (also known as the Krebs cycle).3-7 In its coenzyme form, biotin synthesizes glucose from non-carbohydrate sources, and synthesizes and breaks down certain fatty acids and amino acids.4-7 References Trends Mol Med. 2006 Jun;12(6):247-54. . Med Secoli. 2007;19(1):9-18. . Chem Biol Interact. 2006 Oct 27;163(1-2):94-112. . Mol Genet Metab. 2007 Nov;92(3):222-8. . Arch Med Res. 2002 Sep-Oct;33(5):439-47. Subcell Biochem. 2012;56:1-19. . J Nutr. 2007 Jan;137(1):25-30.

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