Melatonin is a hormone (N‑acetyl-5‑methoxytryptamine) produced especially at night in the pineal gland. Its secretion is stimulated by darkness and inhibited by light. Melatonin, an indole, is synthesized from tryptophan via serotonin. The suprachiasmatic nuclei (SCN) of the hypothalamus have melatonin receptors and melatonin may have a direct action on SCN to help influence circadian (sleep) rhythms.*

Contains no: Gluten, soy, wheat, corn, eggs, dairy, yeast, citrus, preservatives, artificial flavor or color, starch, or sugar. Cautions and warnings: Consumption with alcohol, other medications, or natural health products with sedative properties is not recommended. Consult a health-care practitioner prior to use if you are taking anticoagulants, anticonvulsants, blood-pressure medications, immunosuppressive medications, sedatives, hypnotic or psychotropic medications, or steroids. Consult a health-care practitioner prior to use if you have asthma, cardiovascular disease, chronic kidney disease, depression, diabetes or hypoglycaemia, hormonal disorder, immune system disease, liver disease, migraine, or seizure disorder. Contraindications: Do not use if you are pregnant or breast-feeding. Do not drive or use machinery for 5 hours after taking melatonin. Known adverse reactions: Mild gastrointestinal symptoms (nausea, vomiting, or cramping) have been known to occur; in which case, discontinue use. Rare allergic reactions have been known to occur; in which case, discontinue use. Do not use if seal is broken. Keep out of reach of children.